AMIFOSTINE

Generic Name : AMIFOSTINE

TradeName : AMFOS vial AMIPHOS inj CYTOFOS vial ETHYOL vial M-FOST vial NAPROFOS vi

Why it is prescribed (Indications) : Preventing kidney damage due to chemotherapy and reducing the mouth dryness due to radiation therapy.

When it is not to be taken (Contraindications) : Hypersensitivity, patients with low BP, dehydration, patients with kidney or liver disease, children and elderly >70 yr.

When it is to be taken : As a cell protective agent in chemotherapy and radiation. Adult: Initially, 910 mg/m2 BSA once daily, as an infusion given over 15 minutes, 30 minutes before start of chemotherapy. May reduce to 740 mg/m2 if patient is unable to tolerate the full dose. For patients receiving cisplatin doses <100 mg/m2, a dose of 740 mg/m2 may be given to reduce renal toxicity. Prophylaxis of dry mouth in patients undergoing radiotherapy for head and neck cancer Adult: 200 mg/m2 BSA once daily, as an infusion given over 3 minutes, beginning 15-30 minutes before radiotherapy.

How it should be taken : This medication available in the form of injection, administered by the healthcare providers.

Special Instruction :
• Caution need for pregnant women and breast feeding.
 • Patients should drink water adequately to avoid dehydration.
 Prolonged infusion causes greater side effects.
• Stop antihypertensive drugs 24 hr before infusion.
 • Take antiemetics (drug against vomiting and vomiting sensation) before infusion especially if the treatment causes vomiting.

Side Effects :
HEART:
Low blood pressure during infusion, fall in pulse pressure.
CENTRAL NERVOUS SYSTEM:GI
Nausea, vomiting
MISCELLANEOUS:
Flushing, feeling of warmth, chills, sneezing, cough and skin rashes.

Other Precautions :
Monitor BP regularly, at least before and immediately after infusion

Storage Conditions :
Intravenous: Vials containing lyophilized powder: Store at 20-25°C. Reconstituted solution (500 mg/10 mL): Chemically stable for up to 5 hr at room temperature (about 25°C) or up to 24 hr under refrigeration (2-8°C).