Methoxsalen

Generic Name : Methoxsalen

TradeName : Meladerm,Melanocyl.

Why it is prescribed (Indications) : It is a photosensitiser and is used for the repigmenation of vitiliginous areas.

When it is to be taken : 1.Orally it is given twice a week 2-4 hours before UV exposure with a gap of 48 hours between treatments
2.Topically it is used once a week.

How it should be taken : It is available as tablets or as a solution.The solution is diluted to .1-.01% and applied on the lesions and exposed at once or within 2 hours to UV.

Special Instruction :
It is important that the medication is applied only on the lesions.The surrounding areas should be covered with sunscreen.After treatment the solution should be washed off and the skin protected from sunlight.
It is to be used with caution in pregnancy
,lactation and hepatic impairment.
Foods containing figs,lime,mustard,carrots,parsnips and celery may increase its effect.

Side Effects :
When taken orally its adverse reactions are nausea,insomnia and deprssion.
Topical use may cause itching,edema,headache
,dizziness.
The risk of skin cancer is increased.

Other Precautions :
Contraindicated in hypersensitivity,children,cataract,skin cancer.

Storage Conditions :
Keep in cool place and away from children.