Sirolimus

Generic Name : Sirolimus

TradeName : Rapamune, Siromus

Overview : Sirolimus is used with other immunosuppressants to prevent kidney transplant rejection. It act by suppressing immune system.

Why it is prescribed (Indications) : Sirolimus is used to prevent organ rejection after a renal transplantation. Sirolimus is an immunosuppressant which blocks the action of T lymphocytes which can cause the body to reject the transplanted organ.

When it is not to be taken (Contraindications) : Sirolimus should not be used • If you are allergic to any ingredient in Sirolimus • If you are pregnant • If you have had a liver or lung transplant • If you are taking astemizole, itraconazole, ketoconazole, a macrolide antibiotic (eg, erythromycin), rifabutin, rifampin, tacrolimus, telithromycin, terfenadine, or voriconazole Contact your doctor or health care provide immediately if any of these apply to you.

Missed a Dose? :
• If you miss a dose of Sirolimus, take it immediately. If it is time for your next dose, skip the missed dose and take your regular dosie without fail.

How it should be taken : Use Sirolimus as prescribed by your doctor. • You can take Sirolimus by mouth on an empty stomach or with food. • Clean your hands immediately after taking Sirolimus. • If you are also taking cyclosporine, take Sirolimus 4 hours after your cyclosporine dose unless your doctor instructs you otherwise. • Sirolimus works better if it is taken at the same time every day. Continue Sirolimus even if you feel well. • Do not stop taking Sirolimus without consulting your doctor.

Special Instruction :
Some medical conditions can interact with Sirolimus. Inform your doctor or pharmacist if any of the following apply to you: • if you are pregnant, planning to become pregnant, or are breast-feeding • if you have allergic to any medicines, foods, or substances. • if you have liver problems, kidney problems, diabetes, r breathing problems • if you have had multiple organ transplants, or a previous transplant that has been rejected

Side Effects :
Consult your doctor if any of these side effects persist : back pain; constipation; diarrhea; dizziness; drowsiness; headache; trouble sleeping; vomiting; weakness. Seek medical attention right away if any of these SEVERE side effects occur: Severe allergic reactions,shortness of breath; ; swelling of the hands, ankles, or feet; unusual lumps; unusual tiredness or weakness; unusual weight gain or loss; vision changes; yellowing of the skin or eyes.

Other Precautions :
• Sirolimus can cause dizziness or drowsiness. Avoid driving other unsafe tasks until you know how you react to it. • Do not change your dose of Sirolimus without consulting your doctor. • Inform your doctor if you notice signs of infection like fever, sore throat, rash, or chills. • Sirolimus can increase your risk for developing skin cancer. • Discuss with your doctor before you receive any vaccine. • Inform your doctor if you have dark, tarry, or bloody stools. • Inform your doctor or dentist that you take Sirolimus before you receive any medical or dental care, emergency care, or surgery.

Drug Interactions :
Tell your health care provider if you are taking any other medicines • Angiotensin-converting enzyme (ACE) inhibitors (eg, lisinopril) because a serious side effect involving swelling of the mouth, face, lips, tongue, throat, and hands; trouble swallowing or breathing; and unexplained hoarseness may occur • Aminoglycosides (eg, gentamicin), amiodarone, amphotericin B, azole antifungals (eg, fluconazole, ketoconazole, itraconazole, voriconazole), bromocriptine, cimetidine, cisapride, cyclosporine, danazol, diltiazem, HIV protease inhibitors (eg, ritonavir), macrolide antibiotics (eg, erythromycin), metoclopramide, mibefradil, nicardipine, streptogramins (eg, dalfopristin), tacrolimus, telithromycin, troleandomycin, or verapamil because they may increase the risk of Sirolimus 's side effects, including kidney problems • Astemizole, calcineurin inhibitors (eg, tacrolimus), HMG Co-A reductase inhibitors (eg, atorvastatin), mycophenolate, or terfenadine because the risk of their side effects may be increased by Sirolimus

Storage Conditions :
Sirolimus should be stored at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store in a such a way to avoid heat, moisture, and light.