Generic Name : Sulphamethoxazole Pyrimethamine
TradeName : METAKELFIN
Why it is prescribed (Indications) : Sulphamethoxazole: It is an ultra long acting sulfonamide and in combination with pyrimethamine the effect is super additive. Pyrimethamine is an inhibitor of dihydrofolate reductase. It is a slow acting schizonticide. It can eliminate pre-erytheocytic phase of P.falciparun and secondary tissue phase of P.vivax. It is employed alone development of resistance occurs fast.
When it is to be taken : Adults: Prophylaxis: 1 tab (combination in the ratio of 500mg sulphamethaxarole + 25mg pyrimethamine once a week. Treatment: 2 tabs in a single dose. Children: 9-14 years: 3/4 tab 4-8 years: 1/2 tab under 4: 1/4 tab. All once a week.
How it should be taken : The medication comes in the form of tablets.
Special Instruction :
Check whether you have 6 G6PD deficiency. The drug interacts with antifolic drugs. Do not use these agents while patient is receiving sulfadoxine/pyrimethamine.
Side Effects :
Nausea, vomiting, skin rash, proritus, erythema multiforme.
Other Precautions :
Contraindicated in case of pregnancy & lactation.
Storage Conditions :
Store at room temperature.
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