CYCLOPHOSPHAMIDE

Generic Name : CYCLOPHOSPHAMIDE

TradeName : CYCLOPHOSPHAMIDE vial CYCLOXAN inj CYCLOXAN tab CYCRAME vial CYDOXAN vial CYPHOS vial ELDAMIDE inj ELDAMIDE tab ENDOXAN tab ENDOXAN-ASTA tab ENDOXAN-ASTA vial LEDOXAN inj LEDOXAN tab NEOPHOS vial ONCOMIDE tab ONCOMIDE vial ONCOPHOS vial ONCOXAN vial SHANMYDE vial UNIPHOS tab UNIPHOS vial

Why it is prescribed (Indications) : This medication is prescribed for many types of cancers like lymphatic cancer, cancer of white blood cells and plasma cells, etc, it is an alkylating agent; it slows or stops the growth of cancer cells in your body.

When it is not to be taken (Contraindications) : It may cause bladder bleeding in patients with bone-marrow defect, acute infection, and drug- or radiation-induced urinary tract toxicity, harmful to pregnancy and lactation.

When it is to be taken : 1 to 5 mg/kg daily for both initial and maintenance treatment, adjust dosage according to patient’s condition and body weight.

How it should be taken : Should be taken on an empty stomach.

Special Instruction :
*It may cause blood disorders. *Caution should be exercised in elderly or debilitated, diabetic patients, who have undergone adrenal removal operation. *Monitor blood profile and presence of RBCs in urine regularly. *Maintain adequate hydration and frequent urination to reduce the risk of cystitis.

Side Effects :
Heart:
Acute cardiac toxicity, heart failure, blood in the pericardium, fluid accumulation, irreversible destruction of heart muscle, inflammation of pericardium. CNS:
Lack of energy, general discomfort.
SKIN:
Hair loss, nail changes, skin pigmentation, skin rash, toxic epidermal blistering.
GI:
Abdominal discomfort and pain, loss of appetite, diarrhea, bleeding in colon, sore throat, nausea, vomiting.
Harmone:
Syndrome of inappropriate anti- diuretic hormone hyper secretion
Genitourinary:
Absence of a menstrual period associated with decreased estrogen and increased gonadotropin secretion, atypical urinary bladder epithelial cells in the urine, absence of sperm, urinary bladder inflammation, blood in urine, impairment of fertility, cyst in ovary, death of tubular cells , urinary bladder cyst.
Liver:
Jaundice.
Blood-Lymphatic:
Decrease in all types of blood cells with fever.
Hypersensitivity:
Systemic vasodilatation which results in low blood pressure, including death.
Scarring of both lungs, scarring and thickening of the lung tissues.
Miscellaneous:
Infections, cancers caused by treatment with radiation or chemotherapy.

Other Precautions :
It may cause absence of menstrual period in women.

Storage Conditions :
Store at 25°C. Store it in air tight container and keep away from children.