AMINOCAPROIC ACID

Generic Name : AMINOCAPROIC ACID

TradeName : HAMOSTAT inj HAMOSTAT tab HEMOCID inj

Why it is prescribed (Indications) : This medication is used to control excessive bleeding from systemic hyperfibrinolysis and urinary fibrinolysis.

When it is not to be taken (Contraindications) : Bleeding due to disseminated intravascular coagulation. Rapid IV administration.

When it is to be taken : Oral Treatment and prophylaxis of haemorrhage Initial: 4-5 g, then 1-1.25 g hourly, usually up to 8 hr or until bleeding has been controlled. Max: 30g/24 h0ur. Patients with haemophilia undergoing dental extraction Initial: 6 g immediately after extraction, then 6 g 6 hourly for up to 10 days. IV Treatment and prophylaxis of haemorrhage As 2% solution: Initial: 4-5 g over 1 hour, then continuous infusion of 1 g/hr for usually up to 8 hr or until bleeding is controlled. Max: 24 g/24 hour

How it should be taken : It comes as a tablet and a solution (liquid) to take by mouth. It is usually taken once every hour for about 8 hours or until the bleeding is controlled. When aminocaproic acid is used to treat ongoing bleeding, it is usually taken every 3 to 6 hours. IV infusion Dilute as 1 g/50 mL diluent. Compatible diluents include Sterile Water for Injection, normal saline, D5W, and Ringer's solution. nfuse dose over 30 minute to 1 hour.

Special Instruction :
1. Caution should be exercised in patients with history of urinary tract bleeding, skeletal muscle disease, neonates, small veins in liver are blocked(veno-occlusive hepatic disease), or kidney disease.
2. You should monitor creatinine phosphokinase level regularly.
3. Avoid admin with factor IX complex concentrates and during pregnancy
and lactation.

Side Effects :
HEART- Slow heart rate, low blood pressure, peripheral ischemia; thrombosis.
CENTRAL NERVOUS SYSTEM- Dizziness, headache, delirium, hallucinations, confusion, intracranial hypertension, stroke, syncope.
SKIN- Rash, itching.
EYE ANDENT- Ringing in the ear, decreased vision, watery eyes.
GI- Nausea, diarrhea, abdominal pain, vomiting.
GENITOURINARY- Bladder obstruction due to clot, increased blood, urea, nitrogen, renal failure.
BLOOD- Decrease in white blood cells, thrombocytes, coagulation disorder.
RESPIRATORY- Difficulty breathing or shortness of breath, nasal congestion, blood clot in lungs.
MISCELLANEOUS- Injection site reaction; pain and necrosis, muscle pain, inflammation of your skeletal muscle,; myopathy (characterized by muscle weakness, fatigue, elevated creatinine phosphokinase, rhabdomyolysis associated with myoglobinuria and renal failure), edema; allergic and anaphylactic reactions, malaise.

Other Precautions :
Avoid sudden position changes to prevent low pressure.

Storage Conditions :
Injection: Store at 15-30°C. Store it in air tight container and keep away from children.