VENLAFAXINE

Generic Name : VENLAFAXINE

TradeName : DALIUM tab ENVELAF XR-cap FAXIVEN-XR tab FLAVIX tab FLAVIX XR-tab SENTOSA ER-tab SENTOSA tab VENAXIN-SR SR-tab VENAXIN-SR tab VENDEP XR ER-cap VENFAX-PR ER-cap VENIZ-XR ER-cap VENJOY-XR extentab VENLA cap VENLA suscap VENLIFT OD cap VENLIFT OD tab VENLIFT tab VENLOR tab VENLOR-XR cap VEN-OD cap VENREA ERcap VEXOR extentab

Why it is prescribed (Indications) : This medication referred to cure depression, generalized anxiety disorder, social anxiety disorder, and panic disorder.

When it is not to be taken (Contraindications) : Children less than 18 yr, during pregnancy andlactation. It my cause uncontrolled hypertension; high risk of serious ventricular arrhythmia.

When it is to be taken : For depression initial: 75 mg/day in 2-3 divided doses, increase slowly if needed. Max: 375 mg/day. For anxiety Extended release Initial: 75 mg once daily, may increase slowly if needed. Max: 225 mg/day. For panic disorder 37.5 mg once daily for 1st 7 days, may increase slowly if needed. Max: 225 mg/day.

How it should be taken : This medication available in the form of tablet or extended-release capsule to take by mouth. Take tablet 2times/day.and extended-release capsule once daily in the morning or evening with food.

Special Instruction :
It may cause moderate to severe liver or kidney problems. Conditions which may be worsened by increase in heart rate. • Caution should be exercised in patients with history of heart attack, bleeding disorder, epilepsy, hypomania or mania, elderly, pregnancy. • Monitor BP, serum cholesterol regularly. • Monitor closely during early therapy until depression improves due to increased risk of suicide. • Discontinue if seizure develops or increase in seizure frequency.

Side Effects :
HEART:
widening of blood vessels ; hypertension; palpitation; fast heart beat; low blood pressure; deep vein blood clot, ECG abnormalities (eg, QT prolongation), irregular heart beat.
CENTRAL NERVOUS SYSTEM:
Headache; drowsiness; dizziness, sleeplessness; nervousness; weakness; anxiety; tremor; abnormal dreams; agitation; depression, increased muscle tightness, tingling, twitching; abnormal thinking, confusion; loss of memory, impaired coordination and balance, involuntary movements, shock-like electrical sensations.
SKIN:
Sweating; rash; itching; redness of the skin, toxic epidermal blistering.
Eye and ENT
Throat inflammation; abnormal vision; dilation of pupil, taste perversion, sudden eye pressure, eye bleeding.
GI:
Nausea; dry mouth; loss of appetite; constipation; abdominal pain, diarrhea, vomiting; indigestion; flatulence; eructation; increased appetite; bleeding.
GENITOURINARY:
Abnormal ejaculation; impotence; decreased sexual activity; impaired urination, orgasm disturbance; urinary frequency; albumin in urine, painful menstruation, weak urination, vaginal inflammation; urinary retention.
BLOOD
Discoloration of skin, decrease in white blood cell, decrease in platelets, and neutrophils.
LIVER:
Liver function abnormalities; liver damage, necrosis, or failure, and fatty liver.
LAB TESTS
Increased serum cholesterol, increased Creatine phosphokinase (CPK.)
METABOLIC-NUTRITIONAL
Weight loss; edema, weight gain
RESPIRATORY
Inflammation of bronchus, cough increased, difficulty in breathing; interstitial lung disease.
MISCELLANEOUS
Yawning; chills; flu-like syndrome, infection; accidental injury; chest pain, trauma; joint pain, fever, neck pain, chest pain; birth defect, bleeding, increased prolactin, night sweats, high concentration of eosinophils, kidney failure.

Other Precautions :
• Avoid abrupt withdrawal. Withdraw gradually over at least 1 to 2 week.

Storage Conditions :
Oral: Store below 30°C. Store it in airtight container and keep away from children.