RABEPRAZOLE

Generic Name : RABEPRAZOLE

TradeName : ABRA tab ABRA-D tab ACERA cap ACIDOM tab ACISTAL tab ACISTAL-D cap ADEC tab AFFIRAB tab AFFIRAB-D tab ALBERA enteric-coated tab ALGIBRA tab ANTUC tab ANTUC vial ANTUC-DSR tab APTASE-DSR HG-cap ARIBZOL tab ARIBZOL-D tab ASALT enteric-coated tab ASALT-D cap ASIRAB tab ASIRAB-D tab BIZO tab BIZO-D tab BIZO-DSR tab B-JOY PLUS cap B-JOY tab BRAZO tab BRAZO-D tab BROZOLE-D cap CIDRID cap CINRAB tab COMVINE cap COOLX tab COOLX-D tab CURAB-D cap CYRA tab CYRA-D cap DEGURGE-DSR cap DEPUMP tab DESPRAZOLE tab DEXICOOL tab DEXROBEL-DSR cap DIGERAB-D tab DIGERAB-DSR cap D-KOOL cap DOMRAB cap DORAFEM tab DRAB enteric-coated cap D-RABIBIT tab D-RABIBIT-DSR cap ESOGARD cap FURAB inj FURAB tab

Why it is prescribed (Indications) : This medication is prescribed for duodenal ulcer, gastro esophageal reflux disease (GERD), and Zollinger-Ellison (gastric acid hyper secretion) syndrome. It is in a class of medications called proton-pump inhibitors. It works by decreasing the amount of acid made in the stomach.

When it is not to be taken (Contraindications) : Hypersensitivity, pregnancy.

When it is to be taken : Oral Gastro-oesophageal reflux disease For erosive oesophagitis: 20 mg once daily in the morning for 4-8 wk. Maintenance: 10-20 mg once daily. For non-erosive oesophagitis: 10 mg once daily for 4 wk, upon symptom resolution, may continue with 10 mg once daily when needed. Healing of Duodenal Ulcers: Adults-Oral 20 mg/day after the morning meal for 4 wk; additional therapy may be required for some patients. Zollinger-Ellison – 60 mg once daily. Adjust according to patient’s needs.

How it should be taken : It comes as a delayed-release (long-acting) tablet to take by mouth. It is usually taken once a day for 4 to 8 weeks, but it is sometimes taken for a longer time, with or without food.

Special Instruction :
*Caution should be exercised in patients with history of bleeding ulcer, such as black, tarry stools or vomit that looks like coffee grounds, or if you experience throat pain, chest pain, severe stomach pain, or trouble swallowing contact your doctor immediately.
*May increase the risk of GI infections due to acid suppressive effects, liver damage, gastric tumor.

Side Effects :
CENTRAL NERVOUS SYSTEM- Headache, dizziness, disorientation/delirium.
SKIN- Skin eruptions, severe allergic reactions.
EYE AND ENT- Inflammation of pharynx.
GI- Diarrhea, nausea, abdominal pain, vomiting, flatulence, constipation, abdominal pain, dry mouth.
GENITOURINARY- Kidney disorder.
LIVER- Occurrence of confusion, altered level of consciousness and coma as a result of liver failure (hepatic encephalopathy), inflammation of liver, increased liver enzymes, jaundice.
BLOOD- Decrease in white blood cells, anemia.
METABOLIC-NUTRITIONAL- Excess ammonia in blood, thyroid stimulating hormone elevations.
MUSCULOSKELETAL- Joint pain, muscle
pain, rapid breakdown of skeletal muscle.
RESPIRATORY- Inflammation of lung tissue.
MISCELLANEOUS- Pain, infection, rapid swelling of dermis, coma, sudden death.

Other Precautions :
Avoid abrupt withdrawal.

Storage Conditions :
Oral: Store at 15-30°C. Store it in air tight container and keep away from children.