ONDANSETRON

Generic Name : ONDANSETRON

TradeName : ADOM-O INJ amp AFON MD-tab ANSECARE inj ANSECARE MD-tab ANSET inj ANSET syr ANSET tab BACK2NORM amp C-TRON film-coated tab C-TRON syr DANSET tab DASIN inj DENTRON inj DOMI-UP inj DOMI-UP syr DOMI-UP tab DONSET inj DONSETRON film-coated tab DORAN-O INJ inj DORAN-O tab DOTSON inj DOTSON MD-tab DUTRON syr ELDON inj EMERAN inj EMERAN tab EMESET amp EMESET film-coated tab EMESET syr EMESTAL-O syr EMESTAL-O tab EMESTOP tab EMIGO inj EMIGO syr EMIGO tab EMITINO MD-tab EMITINO syr EMITINO vial EMITUS inj EMITUS MD-tab EMITUS syr EMSETRON inj EMSETRON tab EMSTAL susp EMSTAL tab E-ON amp FLEXI inj FLEXI syr FLEXI tab FODINO amp GENDEM-MD MD-tab GLENDAN syr GLENDAN tab GLOTRON amp KANSET amp KANSET syr KANSET-4 tab KERON tab K-TRON INJ amp K-TRON syr K-TRON tab LUPISETRON 4 inj LUPISETRON inj LUPISETRON PLUS tab LUPISETRON tab MONDA amp MONDA syr MYSET inj MYTIC inj MYTIC syr MYTIC-MD tab NAUCET INJ inj NAUCID inj NAUCID syr NAUCID tab NAUCID vial NEOMIT inj NEOMIT tab NITRON amp NITRON MD-tab NOSIRID drops NOSIRID MDtab

Why it is prescribed (Indications) : This medication is prescribed for nausea and vomiting caused by cancer chemotherapy, radiation therapy and surgery. It is in a class of medications called 5-HT3 receptor antagonists. It blocks serotonin receptors in the vomiting center and on nerves supplying the digestive system.

When it is not to be taken (Contraindications) : Use with apomorphine (profound hypotension).

When it is to be taken : Oral: Prevention of post-op nausea and vomiting 16 mg 1 hour before anesthesia. Nausea and vomiting associated with cancer chemotherapy 24 mg as a single dose 30 minutes before start of single-day chemotherapy. Less emetogenic chemotherapy and/or radiotherapy: 8 mg 2 hr before treatment followed by 8 mg 8-12 hr later.

How it should be taken : It comes as a tablet, a rapidly disintegrating (dissolving) tablet, and an oral solution to take by mouth, and injection administered intravenously. The first dose of ondansetron is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery. Additional doses are sometimes taken one to three times a day during chemotherapy or radiation therapy and for 1 to 2 days after the end of treatment.

Special Instruction :
*It may affect heart rhythm, cause severe liver impairment. *Caution need when used in cardiac diseases, patients who are on medications that can prolong QT or patients with electrolyte abnormalities, during pregnancy and breast feeding. * It may mask progressive ileus and/or gastric distension.

Side Effects :
HEART- Chest pain, tachycardia.
CENTRAL NERVOUS SYSTEM- Headache, seizures, dizziness.
SKIN- Rash.
GI- Dry mouth, constipation, abdominal pain.
METABOLIC- Low potassium in blood, increased level of liver enzymes.
RESPIRATORY- Asthma.
GENITOURINARY- Gynecological disorder, urinary retention.
MISCELLANEOUS- Fever, anaphylaxis, weakness.

Other Precautions :
Do not change the dose, without consulting with your doctor
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Storage Conditions : Oral: Oral solution: Store at 15-30 °C. Protect from light. Tablet: Store at 2-30°C.