METOCLOPRAMIDE

Generic Name : METOCLOPRAMIDE

TradeName : BACNORM drops DONMET inj EMENIL inj EMENIL tab EMENORM inj EMENORM tab LABMET amp MAXERON inj MAXERON syr MAXERON tab MAXINORM tab METADRATE susp METADRATE tab METAJEX inj METARMIN INJ inj METOCLOP amp METOCLOP vial NAUSIFAR MPS gel NAUSIFAR MPS tab PERIGLO amp PERINORM dispertab PERINORM inj PERINORM syr PERINORM tab PERINORM-CD cap PROMET inj REGGI syr REGGI tab REGLAN inj REGLAN syr REGLAN tab REGLAN vial RIVNORM tab SIANORM inj SIGMET inj TOMID syr TOMID tab VOMINORM inj VOMINORM tab

Why it is prescribed (Indications) : This medication is prescribed for heartburn and esophagitis due to GERD and for treating patients who have gastroparesis (partial paralysis of the stomach) and prevention of nausea and vomiting associated with cancer chemotherapy.

When it is not to be taken (Contraindications) : GI hemorrhage, mechanical obstruction and perforation; pheochromocytoma; history of seizures, allergy, pregnancy and lactation.

When it is to be taken : Gastro-oesophageal reflux is 10-15 mg four times daily, 30 minutes before each meal. Gastroparesis is treated with 10 mg administered orally four times daily, 30 minutes before each meal and at bedtime. Nausea and vomiting associated with emetogenic cancer chemotherapy: Adults: IV 2 mg/kg by infusion 30 min before chemotherapy, repeated every 2 h for 2 doses, then every 3 h for 3 doses.

How it should be taken : It comes as a tablet, an orally disintegrating (dissolving) tablet, and a solution (liquid) to take by mouth. It is usually taken 4 times a day on an empty stomach, 30 minutes before each meal and at bedtime. Injection is administered by health care providers into the vein.

Special Instruction :
1. Caution needed for children, elderly, patients with history of liver or kidney disease, porphyria (group of inherited or acquired disorders of certain enzymes), epilepsy, Parkinson's disease, diabetes, history of depression.
2. It may cause dizziness. Do not drive a car or operate machinery until you know how this medication affects you.
3. Do not drink alcohol or use medicines that may cause drowsiness.
4. Do NOT take more than the recommended dose or use this medication for longer than 12 weeks without checking with your doctor.
5. Monitor patients on prolonged therapy. It may lead increased risk of tardive dyskinesia (involuntary movements) in patients on prolonged or high-dose treatment.

Side Effects :
HEART- Acute heart failure, slow heart rate, fluid retention, high blood pressure, low blood pressure, fast heart rate.
CENTRAL NERVOUS SYSTEM- Drowsiness, fatigue, lassitude, restlessness, confusion, depression with suicidal ideation, dizziness, headache, sleeplessness, Neuroleptic malignant syndrome( life- threatening neurological disorder); tremor, involuntary body movements, uncontrolled spasm of muscles face, neck, limbs and body.
GI- Bowel disturbances, primarily diarrhea; nausea.
SKIN- Transient flushing of face or upper body with high IV doses.
HARMONE- Galactorrhea ( spontaneous flow of milk from the breast), breast enlargement in men, increase in serum prolactin.
Genitourinary- Absence of a menstrual period, elevation of aldosterone, fluid retention, impotence, incontinence, urinary frequency.
LIVER- Liver toxicity (rare).
BLOOD- Decrease in white blood cells, changes in hemoglobin.
Hypersensitivity- Rapid swelling of dermis, including glossal or laryngeal edema (rare), rash, itching.
Miscellaneous- Visual disturbances.

Other Precautions :
Insulin dosage or timing of dosage may require adjustment for diabetes patients.

Storage Conditions :
Injection: Store at 25 °C. Store it in airtight container and protect from light.