Aceclofenac

Generic Name : Aceclofenac

TradeName : Acefen, Acefen p, Acenac, Dolokind

Overview : Aceclofenac is an Non-steroidal anti-inflammatory drug (NSAID) used for relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis

Why it is prescribed (Indications) : Aceclofenac is a phenylaceticacid derivative and it is a inhibitor of prostoglandin synthesis and used in rheumatoid arthiritis

When it is not to be taken (Contraindications) : Before taking aceclofenac consult your doctor * If you are pregnant, trying for a baby or breast-feeding. * If you suffer from any stomach problems,liver or renal problems,asthma, heart problems and clotting disorders.

When it is to be taken : It is given as 100 mgs given twice by mouth and should be swallowed with a sufficient quantity of liquid.

How it should be taken : It comes as 100 and 200mgs tablets.

Special Instruction :

* Like other NSAIDs, allergic reactions, including anaphylactic/ anaphylactoid reactions, can occur without earlier exposure to the drug. * Caution should also be exercised in patients with history of coagulation defects and history of liver problems. * Kidney,liver function and blood counts should be monitored during long term treatment. Persistent elevated levels of hepatic enzyme is an indication for withdrawal of aceclofenac . * Chronic heavy alcohol abusers may be at risk of liver toxicity from excessive aceclofenac use. Renal impairment Patients with mild renal function should be monitored regularly since the use of NSAIDs may result in deterioration of renal function. Renal function usually reversible on withdrawal of aceclofenac.

Side Effects :

The most frequent side effects are gastro-intestinal disorders, in particular dyspepsia, abdominal pain, nausea, vomitting, diarrhea, and occasional occurrence of dizziness. Dermatological complaints includes pruritus, rash, abnormal hepatic enzyme and serum creatinine levels have also been reported. In case of serious adverse reactions, Aceclofenac should be withdrawn.

Other Precautions :

Contraindicated in pregnancy,breast feeding and elderly Patients with a history of coagulation,liver dysfunction should use this drug with care. * Aceclofenac should be used with caution in elderly patients with renal, hepatic or cardiovascular impairment.

Drug Interactions :

Aceclofenac can increase plasma concentrations of lithium, digoxin and methotrexate, increase the activity of anticoagulants, inhibit the activity of diuretics, enhance cyclosporin nephrotoxicity and precipitate convulsions when co-administered with quinolone antibiotics. When administeres concomitantly with potassium sparing diuretics (spirinolactone)is employed, serum potassium should be monitored. Hypo or hyperglycaemia can result from the concomitant administration of aceclofenac and antidiabetic drugs. The co-administration of aceclofenac with other NSAIDs or corticosteroids may increase the frequency of side effects.

Storage Conditions :

Store it in air tight container in a cool dry place. Protect from light.