Cholesterol in the blood stream is partially regulated by the brain and not just controlled by what we eat, a study has suggested.The researchers looked for genes with similar patterns of behaviour to those already known to be involved in cholesterol regulation. They then tested the activity of the 100 most promising candidates with a scientific technique called RNA interference (RNAi). The technique uses tiny bits of the genetic molecule RNA to block the protein-making "instructions" issued by genes. In this way, the function of genes can be assessed by effectively switching them off. The strategy identified 20 genes described as "immediately relevant" for maintaining cellular levels of cholesterol. Some them are thought to influence levels of low-density lipoprotein, or "bad" cholesterol, in the blood, a major heart disease risk factor.............&more
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