ANCA/MPO/PR3 Antibodies

Why Get Tested?
To test for certain autoimmune disorders, such as Wegener's granulomatosis (WG), microscopic polyangitis (MPA), and a number of others
When to Get Tested?
When your doctor thinks that you have symptoms that may be due to a vascular autoimmune disorder; sometimes to monitor response to therapy
Sample Required?
A blood sample drawn from a vein in your arm
How is it used?
An ANCA test is ordered to evaluate someone who has symptoms that may be due to autoimmune vasculitis. It may be ordered by itself or along with two other tests that are used to distinguish between different autoimmune disorders. These include:
MPO antibodies
PR3 antibodies
Additional tests that may be performed to aid in a diagnosis include ESR (erythrocyte sedimentation rate) to check for inflammation, CBC (complete blood count) to measure and evaluate white and red blood cells, and urinalysis, BUN (blood urea nitrogen), and creatinine to evaluate kidney function.

Sometimes an ANCA test may be ordered to monitor the response to therapy, follow the course of the disease, and/or to detect a relapse.

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