Mitotane

Generic Name : Mitotane

TradeName : Lysodren

Why it is prescribed (Indications) : This medication prescribed for adrenal cortical cancer which is not treated with surgery. It is an anti-cancer agent which slows growth or reduces the size of the tumor.

When it is to be taken : Oral: Initially 2 to 6 g/day in divided doses, 3 or 4 times daily. Titrate at least 9 to 10 g/day until adverse reactions occur. The maximum tolerated dose ranges from 2 to 16 g/day.

How it should be taken : It comes as a tablet to take by mouth (orally). It is usually taken three to four times a day with or without food.

Special Instruction :
*It may cause drowsiness or dizziness. Do not drive a car or operate machinery while taking this medication.*Monitor adrenal functions, neurological and behavioral signs. *Avoid using in children

Side Effects :
Cardiovascular: Hypertension, sudden fall in blood pressure, flushing. CNS: Lethargy, drowsiness, dizziness, vertigo. SKIN: Skin toxicity. EENT: Non-inflammatory disease of the retina, visual blurring, double vision. GI: Loss of appetite, nausea, vomiting, diarrhea. Genitourinary: Blood in urine, inflammation of the bladder, albumin is present in the urine. Miscellaneous: Generalized aching, extreme elevation of body temperature.

Other Precautions :
After trauma or severe shock, stop the medication.

Storage Conditions :
Store at 77 degrees F (25 degrees C). Store it in air tight container and keep away from children.