Avoid Methylene Blue or Linezolid With Serotonergics

Physicians generally should avoid prescribing either methylene blue or linezolid (Zyvox,Pfizer) in combination with serotonergic agents such as paroxetine or duloxetine to avoid a potential drug interaction causing a dangerous condition called serotonin syndrome, the US Food and Drug Administration (FDA) announced today.
Linezolid is an antibacterial agent, and methylene blue is a dye used in diagnostic procedures and in the treatment of conditions ranging from methemoglobinemia to cyanide poisoning.


Through its Adverse Event Reporting System (AERS) database, the FDA has learned of serious central nervous system reactions when either drug has been given to patients taking other drugs that work through the serotonin system of the brain.

Both linezolid and methylene blue — each the subject of separate FDA press releases — inhibit the action of monoamine oxidase A, an enzyme that breaks down serotonin. Either drug, it is believed, can cause high levels of serotonin to build up in patients taking serotonergics, leading to the toxic condition called serotonin syndrome. Signs and symptoms include confusion, hyperactivity, and other mental changes; muscle twitching, excessive sweating, shivering, or shaking; diarrhea; trouble with coordination; and fever. In the case of linezolid, some deaths have been reported.

The FDA is advising clinicians that certain emergencies or life-threatening conditions warrant the administration of linezolid or methylene blue in patients taking serotonergic drugs. Linezolid may be needed for such patients to treat vancomycin-resistant Enterococcus faecium infections, or infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Methemoglobinemia, cyanide poisoning, or ifosfamide-induced encephalopathy may require the emergency administration of methylene blue, according to the FDA.

In nonemergency situations, most serotonergic drugs must be discontinued at least 2 weeks before the start of linezolid or methylene blue therapy. Fluoxetine requires a 5-week lead time because of its longer half-life.

The FDA said that these and important recommendations as well as safety information about the potential interaction with serotonergic drugs will be added to the label of linezolid. The labels for serotonergic drugs will also be revised accordingly.

The agency is instructing patients taking either combination of drugs not to discontinue their serotonergic medication without first talking to their healthcare professional.

8 comments:

  1. Buy Fildena 150mg Online is used for Enlarged prostate gland in male, Increased blood pressure in lungs and other conditions. Know about the uses, side effects, price, composition, substitutes, How it works, Lowest Price Online Fildena 150mg Online buy with lowest Price Ever Online Pharmacy. Fildena 150mg Reviews.

    Buy P Force Fort 150mg Online is used for Penis erection, High blood pressure and other conditions. P Force Fort 150mg Tablet may also be used for purposes not listed in this medication guide. Order P Force Fort 150mg Online From Trusted Online Pharmacy Medypharma . Best Price In USA.

    Buy Super P Force Online is used for Penis erection, High blood pressure and other conditions. Super P Force Tablet may also be used for purposes not listed in this medication guide. Order Super P Force Online From Trusted Online Pharmacy Medypharma . Best Price In USA.


    Buy Vigora 50mg Online is used for Penis erection, High blood pressure and other conditions. Vigora 50mg Tablet may also be used for purposes not listed in this medication guide. Order Vigora 50mg Online From Trusted Online Pharmacy Medypharma . Best Price In USA.

    Buy Tadarise 10mg Online is a name for generic Cialis, an erectile dysfunction medication based on Tadalafil. Know about tadarise 10 mg uses , Price , How to take , Side Effect , How to use .cheap Tadarise 10 avail in USA. Tadarise Review by Online Trusted Pharmacy Medypharma. Order Tadarise Now !

    ReplyDelete
  2. Buy zenegra 100 Online is used for Penis erection, High blood pressure and other conditions. zenegra 100mgTablet may also be used for purposes not listed in this medication guide. Order zenegra 100mg Online From Trusted Online Pharmacy Medypharma . Best Price In USA.

    Buy vilitra 10 Online is used for Penis erection, High blood pressure and other conditions. Vilitra 10mg Tablet may also be used for purposes not listed in this medication guide. Order Vilitra 10mg Online From Trusted Online Pharmacy Medypharma . Best Price In USA.

    Buy zhewitra 10 Online contains Vardenafil . It's effective erectile dysfunction medication and works for almost all men. Zhewitra 10 mg Price has a fast action time and last up to 50% longer than Sildenafil Citrate. Best Avail Price of Zhewitra 10 mg in USA From Medypharma . Order Now !

    Buy duratia 30 Online is prescribed for the treatment of Erectile Dysfunction in men. Know about Depoxetine 30 mg Side effects , uses , How to take , How to Use. Duratia 60 mg contain of depoxetine 60mg Lowest Price Online. Buy At Trusted Online Pharmacy Medypharma. Order Now !

    Buy duratia 60 Online is Manufactured by Fortune Healthcare. It's prescribed for the treatment of Erectile Dysfunction in men. Know about Depoxetine 30 mg Side effects , uses , How to take , How to Use. Duratia 60 mg contain ofdepoxetine 60mg Lowest Price Online. Buy At Trusted Online Pharmacy Medypharma. Order Now!

    Buy duratia 90 Online is Manufactured by Fortune Healthcare. It's prescribed for the treatment of Erectile Dysfunction in men. Know about Depoxetine 30 mg Side effects , uses , How to take , How to Use. Duratia 60 mg contain of depoxetine 60mg Lowest Price Online. Buy At Trusted Online Pharmacy Medypharma. Order Now!

    Buy poxet 90 Online is a treatment for men premature ejaculation (PE) problems. poxet 90 mg online from your most reliable Trusted online pharmacy Medypharma. Avail best price in USA, by your doorsteps. Order poxet 90 Now!, dapoxetine 90 mg reviews , poxet 90 mg price in india

    Buy kamagra Oral Jelly Online made by Ajanta. cheap kamagra oral jelly in USA from trusted Online Pharmacy Medypharma. kamagra oral jelly for sale , kamagra oral jelly price in india , kamagra oral jelly review. Order Now !

    ReplyDelete
  3. Buy Cenforce 200mg Online is a perfect and effective drug for the treatment of erectile abnormality within the men. cenforce 200 mg from your most reliable Trusted online pharmacy Medypharma. by your doorsteps, Avail best price in USA. cenforce 200 review, cenforce 200 directions.

    Buy Fildena 50mg Online is used for Enlarged prostate gland in male, Increased blood pressure in lungs and other conditions. Know about the uses, side effects, price, composition, substitutes, How it works, Lowest Price Online Fildena 50mg Online buy with lowest Price Ever Online Pharmacy. Fildena 50mg Reviews.

    Buy Vidalista 20mg Online is use to treatment of erectile dysfunction (ED) in men. buy vidalista online is contain of Tadalafil. Vidalista is also know as Generic Cialis. Vidalista 20 review is manufactured by centurion laboratories. Vidalista 20 dosage, vidalista 20 mg reviews, What is Vidalista.

    Buy Tadalista 40mg Online is an oral medication for the treatment of erectile dysfunction (ED). buy tadalista online is containt of Tadalafil. Know about Tadalista uses , Price , How to take , Side Effect , How to use tadalista .cheap tadalista in USA from Medypharma.

    BuyKamarga 100mg To all the men who feel disappointed due to the heavy-prices of Viagra, they should place their trust in Kamagra 100 mg— the ideal alternative of Viagra which treats impotence using Sildenafil

    ReplyDelete
  4. Buy Tadagra 20 online is an erectile dysfunction remedy which is used to treat erectile dysfunction in men over 18 years of age. Erectile dysfunction is defined as inability to achieve and maintain erection enough for the sexual intercourse. The active ingredient of the medication is tadalafil which is PDE5 inhibitor.

    ReplyDelete
  5. Buy cenforce 100 has sparked happiness and joviality in the minds of the people who can’t spend thousands of dollars on blue pills for overbearing erectile dysfunction. Its active component— Sildenafil makes sure that this generic-variant stays effective.

    Buy cenforce 120 is a beaming light in the dark life of the people experiencing hardship by their inability to achieve erection (erectile dysfunction). The drug contains the therapeutic-substance, Sildenafil, which relaxes penile arteries for better Flow.

    Buy cenforce 200 is a mighty drug to combat erectile dysfunction (ED) in men. As it is rich in Sildenafil Citrate, it ensures that the PDE5 enzymes keep distance from cGMP neuro-molecules which carry the sexual information between the brain and the penis.

    Buy cenforce 150 is all prepared to stitch happy stories for the men who have been battling erectile dysfunction (ED) in and out. The drug is a potential generic-replacement of Viagra which constitutes Sildenafil for boosting the blood flow in the penis.

    Buy cenforce 25 is looking forward to charging the men who have been cursing their dull sex life due to their lethargic penis. The vital ingredient— Sildenafil Citrate— makes sure that men get enough blood supply to the penis for erection.

    Buy cenforce 50Among the diversified family of Cenforce, Cenforce 50 Mg is one of the essential drugs for managing erectile dysfunction (ED) in men. The medicine is jam-packed with Sildenafil which projects the gleaming hope by boosting the blood supply in the penis.

    Buy cenforce d may settle in as a revolutionizing medical idea to overbear erectile dysfunction (ED) in men. The Pills is fully-loaded with Sildenafil which enhances the cGMP volume in the blood for relaying sexual stimulation between the brain and the penis.

    Buy cenforce fm 100 is a mighty Sildenafil-Citrate solution against erectile dysfunction (ED) in men. The drug promises to stave off the erection issues by supplying plentiful blood in the penis and humiliation by empowering the powerful shaft salute.

    Buy cenforce professional can alter the medical status regarding the erectile dysfunction (ED) in men drastically by its generic-chemical formula— Sildenafil Citrate which popularly erects the penis by inflating the required blood flow in it.

    Buy cenforce Soft may chip-in as the perfect affordable solution for erectile dysfunction (ED) in men. All the men who are tired of spending bucks after bucks for handful of Viagra tablets have got the desirable and impactful drug at lesser rates.

    ReplyDelete
  6. This is a useful blog, and thanks for giving us nice information! 

    CENFORCE 200 MG Tablet

    ReplyDelete
  7. https://www.beemedz.com/tadalista-super-active/

    Tadalista Super Active is a treatment for erectile dysfunction. The medicine is a drug that can be taken orally, and is an alternative to Viagra. The medicine is manufactured by Cipla. Tadalafil helps relax the muscles of the penis and allows blood to flow into the penis more easily. Tadalafil is a phosphodiesterase type 5 inhibitor. It works by preventing the action of an enzyme called phosphodiesterase type 5 (PDE5). This allows the accumulation of nitric oxide and cyclic guanosine monophosphate in the corpus cavernosum, which increases blood flow to the penis and helps to maintain an erection. Tadalista Super Active is taken orally with water, with or without food. The maximum recommended dose is one tablet taken once per day. Some people taking Tadalista Super Active have experienced side effects such as headaches, dizziness, back pain, or muscle pain.

    ReplyDelete
  8. https://www.beemedz.com/tadarise-40-mg/
    Tadarise 40 Mg is a powerful erectile dysfunction treatment. The active ingredients in Tadarise 40 Mg are Tadalafil. These medications work together to provide long-lasting erections, an increase in blood flow to the blood vessels, and an increase in the intensity of orgasm.

    ReplyDelete